抗小鼠血小板减少(CD42b )抗体 Antibodies for Platelet Depletion in mouse

背景资料: This antibody preparation contains a mixture of purified rat monoclonal antibodiesdirected against mouse GPIb (CD42b). Targeting of this receptor with divalent IgGs results inprofound and i

  • 货号: R300 (emfret)
  • 背景资料: 

    This antibody preparation contains a mixture of purified rat monoclonal antibodies directed against mouse GPIb (CD42b). Targeting of this receptor with divalent IgGs results in profound and irreversible Fc-independent platelet depletion in mice1,2 . Platelet depletion is frequently used to study the general role of platelets in (patho-) physiology3 .

    保存条件:

    The antibodies were purified from hybridoma cell culture supernatant by Protein G-Sepharose chromatography. 

    Stable for six months from date of shipment when stored at 4°C. 

    KEEP STERILE, the preparation contains no preservative. Aliquots can be stored at -20°C for at least one year. Avoid repeated freezing and thawing.

    应用:

    This preparation is optimized to reduce the platelet count by >95% within 60 minutes after intravenous injection of 2 µg/g bodyweight. It is recommended to inject the antibodies in a volume of 100-200 µl (diluted with sterile PBS).

    同型对照(抗体来源): Rat IgG (Wistar)

    缓冲液: 0.5 mg purified immunoglobulins in PBS, 0.2% (w/v) BSA, sterile filtered

    浓度: 0.5 mg/ml

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